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This tumor angiogenesis core gene signature also included CLEC14A and CD93, which together with endosialin and thrombomodulin constitute a C-type lectin family that are frequently up-regulated in tumor vessels [95, 101,102,103,104,105,106]
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Nicholas, S., Yuan, S
Among the secreted factors, extracellular vesicles (EVs) and mainly exosomes have emerged as novel communication vehicles that have been detected in the TME and are increasingly understood as key players in tumor growth and spread [133,134]
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