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Pathophysiology Crohns disease results from a dysregulated immune response to intestinal microbiota in genetically susceptible individuals, as described by StatPearls (NCBI)

The numbers of surviving neurons and oligodendrocytes were significantly increased in treated animals compared to controls

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The most common adverse events were mild-to-moderate headaches, similar in frequency to placebo groups

So they could opt instead to use the synthetic version instead of the extract