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Moore, Jr DF, Andreeff M

Signal integration is accomplished by the assembly of cytosolic pattern recognition receptors (PRRs), including nucleotide oligomerization domain (NOD)-like receptor (NLR) family pyrin domain containing 1 (NLRP1), NLRP3, NLRC4, absent in melanoma 2 (AIM2), and pyrin, and activation of caspase-1

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However, due to oxidative stress caused by lipid peroxidation, glycolysis, one of the key metabolic ways of TANK cell effector function, is reduced, which in turn inhibits its anti-tumor function and makes cancer progression

M., Zhang H., Pahl E., Purves R