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doi: 10.1007/s00239-024-10223-7 2 HaleniusAGerkeCHengelH

Protection against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity by the antioxidant ascorbic acid

Also, GB modulates the activity and expression of specific ion transporters and channels, such as H + -ATPases and metal transporter families (ZIP, NRAMP), enhancing selective uptake and sequestration of essential ions while limiting toxic metal accumulation (Hasanuzzaman et al., 2020)

Their GATA1 mutations are frameshifts in exon 2 that result in the failure to make GATA1 protein, continued formation of GATA1-S, and thus a greatly reduced ability to regulate GATA1-targeted genes

The benefits of cladribine for the treatment of progressive MS remains to be explored in further clinical trials (ClinicalTrials.gov NCT04695080, NCT04550455)
