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As an important part of metabolic reprogramming in the tumors, reprogramming of glutamine metabolism is considered to have pleiotropic effects on cellular functions, such as macromolecule synthesis, energy generation, mTOR activation, maintenance of reactive oxygen species (ROS) balance and anti-tumor acidic microenvironment
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This is important because tropical waters are usually low in nutrients, so the nitrogen that whales release can help fertilize these ecosystems and support marine life like plankton, which form the base of the food web

Beta-cell uncoupling protein 2 regulates reactive oxygen species production, which influences both insulin and glucagon secretion

Cacciatore I, Cornacchia C, Pinnen F, Mollica A, Di Stefano A