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The causative mutations fall into two categories: (1) 0 mutations, associated with absent -globin synthesis, and (2) + mutations, characterized by reduced (but detectable) -globin synthesis

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The restricted expression of PC in astrocytes was first demonstrated in primary cultures (Yu et al

The identification of GHB is paramount in forensic and clinical toxicology where GHB could be quickly metabolized and has a limited detection time in biological specimens 1,3
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ClinicalTrials.gov registry search: mecasermin (native recombinant human IGF-1)
