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Through its activation of the phosphoinositol-3 kinase pathway and phosphorylation of the X-linked inhibitor of apoptosis protein (XIAP), IGF-1 acts to protect Kpffer cells and counter the potentially lethal effects of sepsis

The concentration was then adjusted to 0.2 M, and the excitation spectra (350 nm to 500 nm, fixed emission at 510 nm, bandwidth: 5 nm) were recorded in an FP-8500 spectrofluorometer (Jasco, Tokyo, Japan) at 25 C with continuous stirring for at least 1 min

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Results Effects of hyperforin on prostanoid formation in human whole blood Hyperforin was recently shown to inhibit the production of PGE 2 in LPS-stimulated RAW264.7 mouse macrophages (Hammer et al., 2 formation with an apparent IC 50 of approx

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