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The absence of labelling in vacuoles demonstrates that GSH-metal complexes, which are not recognized by the present immunohistochemical approach, are sequestered to this compartment after complexation in the cytosol

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Ayoubi M, Thomas DA, Kantarjian H, O'Brien S, Ravandi F, Garcia-Manero G, Verstovsek S, Rytting M, Borthakur G, Kadia T, Kornblau SM, Andreeff M , Feliu J, Faderl S