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These include the need for integrated structural-molecular evidence, deepened mechanistic insights, clinical validation and assessment of how broadly synapse-mediated neuroprotection and regenerative signaling generalize across the CNS

Because of its specialised profile, it is often explored in experimental settings focused on endocrine function, metabolic studies, and peptide-based research

Kwong WT, Fehmi SM

Vitamin B6-dependent epilepsy is a group of autosomal recessive disorders caused by mutations in the genes for phosphatidylinositol binding protein (PLPBP), acetaldehyde dehydrogenase 4 family member A1 (ALDH4A1), acetaldehyde dehydrogenase 7 family member A1 (ALDH7A1), pyridoxal (amine) 5'-phosphate oxidase (PNPO), and tissue non-specific alkaline phosphatase (TNSALP)

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