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doi: 10.1016/j.tig.2015.11.001 [DOI] [PMC free article] [PubMed] [Google Scholar] 22.Crouch J, Shvedova M, Thanapaul RJRS, Botchkarev V, Roh D

In the case of semaglutide and tirzepatide, this overlap could lead to: Stronger gastrointestinal side effects Excessive appetite suppression Increased risk of dehydration Greater metabolic stress on the body Another important factor is that there is limited clinical research studying the combined use of these medications