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Understanding Multiple Sclerosis and Research Innovations Multiple sclerosis (MS) is a chronic disease affecting the central nervous system, leading to symptoms such as fatigue, difficulty walking, and muscle weakness

GSTO1 has been shown to play a significant role in the protein glutathionylation cycle exhibiting both glutathionylation and deglutathionylation activities 11,15

So you don't make assumptions and don't make anecdotal claims, because when multiple factors change simultaneously, we have to have a more systematic approach, and we're all about systems, we're all about analysis and there are still ways that you can kind of tease out the data

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(2) GSH depletion induced by APAP leads to decreased cellular NADPH/NADP + ratios, which is known to activate glucose-6-phosphate dehydrogenase allosterically to enhance oxidative pentose phosphate pathway flux