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Acknowledgements Not applicable Funding No specific funding was received for this study

The project was sponsored by the Fund of the Second Hospital of Tianjin Medical University (No.2023ydey07)

In animal models of PE, ozone exposure led to enhanced activity of glutathione peroxidase, superoxide dismutase, and catalase, consistent with activation of the nuclear factor erythroid 2-related factor 2 (Nrf2) signaling pathway

Cobalamin deficiencies or a lack of Vitamin B12 can also lead to issues such as anemia or the feeling of fatigue and cognitive problems in most people

Moreover, due to the score of the high purity of the N-Hcy-Lys peak, we can prove that the obtained concentration of the analyte in analyzed plasma samples could not be increased by signals of other compounds