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In this paper, we present a new integrated model for hepatic glutathione metabolism including one-carbon metabolism and use it to investigate how the activation of certain enzymes by estradiol in one-carbon metabolism and glutathione metabolism leads to dramatic changes in reaction velocities and metabolite concentrations, including GSH and the GSH synthesis rate
Paramsothy S., et al
Even though some studies have shown that alveolar type II cells can supplement endogenous synthesis of GSH with the uptake of exogenous GSH (11, 12), the antioxidant effectiveness of exogenously administered GSH is hindered by its instability when crossing cell membranes and its rapid hydrolysis in the circulation (13-15)
Wellner VP, Sekura R, Meister A, Larsson A
