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Pharmacotherapy [12, 13] consists of four categories of drugs: (1) First-line drugs like anticonvulsants (gabapentin, pregabalin, and carbamazepine) and antidepressants (amitriptyline, duloxetine, and venlafaxine)

doi: 10.1016/S1726-4901(09)70119-4

Their findings demonstrated that lectin administration significantly alleviated hypernociception, with the most pronounced effect observed at a dose of 10 mg/kg

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Specifically, while inhaled gentamicin and inhaled colistin have demonstrated potential, clinical trials involving inhaled tobramycin, aztreonam, and ciprofloxacin (both dry powder and liposomal formulations) have failed to achieve the predefined study endpoints ( Retrospective studies on Pseudomonas aeruginosa have reported initial eradication rates of bronchiectasis via various regimens, including oral, inhaled, and intravenous antibiotics, ranging from 52% to 80%