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In fact, in a study from Denmark, there was a trend for a protective effect for the variant (Leu) allele in lung cancer cases compared to controls (296), and, similarly, other studies have found a protective effect for the Leu allele (144, 399)

Insulin receptor substrate (IRS)-2, not IRS-1, protects human neuroblastoma cells against apoptosis

Akeda et al
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It supports the expression of genes responsible for DNA repair, which results in slower cell aging and longer cell lifespan
The Global Economic Burden of Non-Communicable Diseases
