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Design and statistical innovations in a platform trial for amyotrophic lateral sclerosis
doi: 10.1089/thy.2007.0069 30 PlioplysAPlioplysS
Conversely, high BMI exacerbates neuroinflammation through adipokine dysregulation: leptin resistance suppresses hippocampal BDNF, impairing cognitive recovery, while gut dysbiosis depletes Akkermansia, reducing SCFA production by 40% and compromising BBB integrity [247]
These participants incorporated MCT oil into their diet, following a tolerance-based regimen of twice-daily supplementation for a three-month period
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