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Excess testosterone can slow or stop ovulation, contributing to the anovulatory cycles

This compound has been the subject of intense study in the scientific community

doi: 10.1021/acs.biochem.3c00373

Eisenberg MA, Werner R, Ries S, Hofstetter WL, Mehran RJ, Papasotiropoulos T, Rice DC, Rajaram R, Steinmann N, Swisher SG , Walsh GL, Vaporciyan AA, Opitz I, Antonoff MB

Icariin II (ICS II), a flavonoid from Epimedium koreanum , triggers ferroptosis in renal carcinoma by downregulating GPX4 in a p53-independent manner and upregulating miR-324-3p, which suppresses GPX4 expression, leading to iron accumulation, lipid peroxidation, and GSH depletion (234)