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10.1016/j.bbagen.2012.09.008 65 MakT
PROTACs generally comprise three key components: a small molecule that specifically binds to the protein of interest (POI), an E3 ligase ligand, and a linker [127]

[71] Serum IgA was significantly correlated to the severity of illness

Thus, there is considerable protein synthesis during cystine starvation which depletes amino acids and causes a reduction in mTORC1 signaling
