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Post mortem evaluation of inflammation, oxidative stress, and PPARgamma activation in a nonhuman primate model of cardiac sympathetic neurodegeneration

SPRMs are a class of drugs that specifically target PR, competitively inhibiting the binding of endogenous progesterone to PR and thereby reducing progesterone activity [170]

Lancet Oncol 25(3):366-375, 2024
The cardiovascular roles of copper are multifaceted

Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to regularly evaluate renal function
