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However, due to the low solubility and high metabolism of naringenin, its bioavailability before entering the systemic circulation is poor, which hinders its clinical efficacy (84)

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10.17179/excli2021-3668 [DOI] [PMC free article] [PubMed] [Google Scholar] Kovaleva V, Yu LY, Ivanova L, Shpironok O, Nam J, Eesmaa A, Kumpula EP, Sakson S, Toots U, Ustav M, Huiskonen JT, Voutilainen MH, Lindholm P, Karelson M, Saarma M (2023) MANF regulates neuronal survival and UPR through its ER-located receptor IRE1

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