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These data illustrate a key paradox: p21, once heralded as a tumor suppressor, can become a protector of malignant cells under therapy pressure

TRMA is also referred to as thiamine metabolism dysfunction syndrome 1 (THMD1)

In contrast, when PKM2 exists in its monomeric or dimeric form, it can enter the nucleus and function as a coactivator for several transcription factors (such as HIF-1, -catenin/c-Myc, NF-B, and STAT3), regulating metabolic reprogramming and gene expression to meet various physiological demands [49]

Mammalian autophagy: Core molecular machinery and signaling regulation

Plate B (MSG 925 mg/kg) shows normal mammary gland histoarchitecture with irregular alveoli branching lined with fat globules, numerous alveolar milk lumens containing milk, and a defined alveolar epithelium
