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There was an overall weight gain in these patients and a decrease in the frequency of clinical signs such as vomiting and diarrhea

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doi: 10.1016/j.jfca.2019.103386 90

Based on the skeleton of 2-amino-3-cyano-6-(2-hydroxy-phenyl)pyridine, a series of inhibitors were designed and synthesized, yielding compounds 69-74 [180, 181]

These are tiny, uncontrolled experiments, but they demonstrate how impacts can be marginal and diverse