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This lipotoxicity and oxidative stress vicious cycle creates a metabolic trap, which is particularly evident in glomerular mesangial cells and proximal tubular cells, thereby driving extracellular matrix deposition and the development of renal fibrosis

- Sodium Hyaluronate (HA) 5%: phc hi m cn thit cho ln da bng nhiu kch thc phn t khc nhau gn cht vi tng lp biu b da hp th nc v gi nc gip ln da tr nn mn mng, n hi v cng bng

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Leptin receptor signaling pathway defects, ER stress, and decreased leptin transport across the BBB are some possible explanations [84,85,86]

Tron et al., 2018)
