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Conclusion Whilst severe B12 deficiency has a clear clinical picture with characteristic haematological and/or neurological features, establishing mild or borderline deficiency can be problematic as serum levels are maintained at the expense of tissue concentrations, and therefore serum levels of B12 may be in the low normal or borderline range despite a deficiency

Swaminathan et al

Species Selection for PK Evaluation Species used in PK testing must be suitable for in vitro/in vivo predictions and be clinically relevant

[DOI] [PMC free article] [PubMed] [Google Scholar] 68.Wei T., Cheng Q., Min Y.L., Olson E.N., Siegwart D.J