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Molinari, H

Excessive activation of NMDA-type receptors leads to uncontrolled Ca 2+ influx and overproduction of nitric oxide (NO), culminating in neuronal damage and cell death (Bonfoco et al

694,821,822 Pharmacological interventions hold potential for liver regeneration

Microglial phenotype modulation: Affects microglial gene expression shifting from pro-inflammatory M1 phenotype to anti-inflammatory M2 phenotype

Overall, the position of different mutations can affect protein catalytic activity and stability to various degrees, with mutations in specific region of the protein leading to more severe deficiency