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LC-MS was carried out on an Ultimate 3000 Rapid Separation LC (Thermo Fisher Scientific) coupled to a quadrupole Orbitrap ion trap mass spectrometer

When -oxidation is limited, tumors avoid ferroptosis by (i) reducing PUFA incorporation into membranes 346 , (ii) deploying extramitochondrial ubiquinol recycling to trap lipid radicals 347,348 , and (iii) using the mitochondrial dihydroorotate dehydrogenase-ubiquinone axis to detoxify lipid peroxides in the inner membrane 349

doi: 10.1016/j.jfma.2017.09.006

It also helps evenly disperse other ingredients

In our work, reduction of tyrosine nitration by either nicotinamide or EGCG treatment in old age neurons suggests a combination antioxidant effect