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Consequently, inhibiting/conquering ROS production and augmentation of cellular antioxidant machinery alleviated 5-FU-associated kidney damage (42, 43)

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PLoS One 7:e37395 Sun J, Schnackenberg LK, Holland RD, Schmitt TC, Cantor GH, Dragan YP, Beger RD (2008) Metabonomics evaluation of urine from rats given acute and chronic doses of acetaminophen using NMR and UPLC/MS

The robust regulation of CDO in mammalian tissues by intracellular Cys levels and the direct correspondence of Cys levels with CDO levels in liver and adipose tissue suggest that CDO plays a role in controlling steady-state intracellular Cys levels