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In functional medicine, those clues matter because they point toward systems that change over time and might be modifiable

In the endothelial cells, the correct functionality of the cell barrier is coordinately governed by Rho GTPases, including Rac1

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Further research has demonstrated that this dysregulation of the negative feedback mechanism plays a vital role in PTSD, potentially being a key factor causing the persistence of chronic stress states (Sriram et al., 2012)

10.1007/s00198-011-1676-0 97 KogaT.InuiM.InoueK.KimS.SuematsuA.KobayashiE.et al (2004)