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This work showed that PTU-induced hypothyroidism caused damage to sinusoidal cells, causing the structure to appear dilated

Shandra, A

& Healy, J

Copper accumulation in the synovial membrane and cartilage has been suggested as the major cause of osteoarthritis and accelerated degenerative changes with deformities affecting particularly larger joints 90

The identification of two forms of MAO, known as MAOA and MAOB, and their respective selective inhibitors has contributed to a better understanding of their physiological roles, regulation of neurotransmitter metabolism and the mechanism of the 'cheese reaction', and has led to the development of selective inhibitors that avoid this side effect