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Functional validation demonstrated PIEZO1-dependent mitochondrial translocation of TMBIM6, restoration of PHB2 S91 phosphorylation status, and subsequent enhancement of mitophagy-ERphagy coordination, ultimately promoting mitochondrial DNA stability and ATP synthesis while inhibiting DOX-induced pyroptosis

Infusion therapy is a broader term referring to any treatment delivered directly into the bloodstream via a needle or catheter

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Abbreviations Author Contributions All authors contributed substantially to the preparation of this study