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Conversely, the increased export of 2-Oxoglutarate into the cytosol could augment the activity of Fe (II) 2-oxoglutarate (2OG)dependent oxygenases, enzymes that catalyze a variety of critical reactions including hydroxylation, halogenation, desaturation, and ring transformation

Another characteristic of PD is the loss of dopaminergic neurons in the substantia nigra and the subsequent decrease in dopamine levels in the substantia nigra striatum

Dissociative anesthetics (ketamine and nitrous oxide) impair glutamatergic neurotransmission and mitochondrial function, contributing to excitotoxicity and neurodegeneration

And so it's a huge thing

Additionally, numerous factors like stress, unhealthy lifestyles, and pollutants can accelerate this process, causing bouts of exhaustion in affected individuals