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MSCs possess remarkable multilineage differentiation potential, giving rise to osteoblasts, chondrocytes, and adipocytes, which enables their application in the repair of bone, cartilage, and soft tissues

Nicotinamide mononucleotide induces lipolysis by regulating ATGL expression via the SIRT1-AMPK axis in adipocytes

And then it lead to body inflammation (Mittal et al., 2014), cellular damage and death (Dixon & Stockwell, 2014)

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Glutamate Modulation: NMDA receptor antagonists (e.g., memantine) and AMPA receptor antagonists are also used to prevent glutamate-mediated excitotoxicity and reduce seizure frequency