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It has been shown that oral betaine intake at 6 g/day decreased the fasting plasma homocysteine concentrations significantly in healthy humans (Olthof et al., 2003

A multicenter study of nutraceutical drinks for cholesterol (evaluating effectiveness and tolerability)

Sawicka AK, Hartmane D, Lipinska P, Wojtowicz E, Lysiak-Szydlowska W, Olek RA

In females, positive correlations were identified between serum L-C and obesity, total cholesterol, glucose, insulin, and insulin resistance in those with normal fasting glucose level, but not if hyperglycemic

Acylcarnitine also plays a role in the pathological development of nonsteroidal anti-inflammatory drug-exacerbated respiratory disease (N-ERD) by affecting the DNA methylation pattern of macrophages and directing macrophage function in a proinflammatory direction [45]
