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This almost mirrors the evidence from Mendelian randomisation studies on genetic exposure to lifelong lower LDL-C levels, where there is a 54% relative risk reduction of coronary heart disease (95% CI, 0.41-0.52) per each 1.0mmol/L lower long-term exposure to LDL-C was

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Any suspicious pigmentary lesion with irregular or asymmetric margins or those that are ulcerated, exophytic, or heterogeneous should be excised and assessed to exclude melanoma[78,92]

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