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and 3) Iron deficiency possibly affects macrophage function in marrow causing delayed extrusion of the nucleus of erythroid progenitors so they cannot be released from marrow (a protein in erythroblasts called erythroblast macrophage protein is required for their interaction with macrophages and extrusion of their nuclei

The time taken to reach this threshold level in the control animals was 12 min

VaD can be triggered by CCH and reduced cerebral blood flow, leading to cerebrovascular lesions or impaired blood supply, ultimately resulting in blood vessel rupture and erythrocyte cleavage

In rare cases, some individuals may experience discomfort due to personal constitution or health condition
