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Examples of such conditions include myeloproliferative disorders (e.g., chronic myelogenous leukemia, polycythemiavera), severe liver diseases, and alcoholism
doi: 10.1016/j.nutres.2012.03.009
Chronic fatigue, exercise intolerance, age-related energy decline, mitochondrial dysfunction, poor recovery capacity, and metabolic sluggishness that doesn't improve with sleep or nutrition changes
While supplementing with large doses of B12 will reduce MMA levels more than will smaller doses, there are no clear benefits (more info in Appendix A
Most reactions are treated and cause no permanent harm
