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DKD, characterized by persistent proteinuria and/or a progressive decline in glomerular filtration rate, is one of the most prevalent complications of DM and a leading cause of end-stage renal disease (ESRD) 3
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The C-H bonds adjacent to the C = C double bond in these phospholipids are highly unstable and susceptible to reactive oxygen species (ROS) attack, triggering lipid peroxidation chain reactions [9, 10]
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Even those positive effects of metformin, the limitation of use has been highlighted
