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This finding could be explained by the previous in vitro data (Rathz et al., 2002) given that 1 -AR overactivation increases the workload on a failing heart (Masarone et al., 2021)

doi: 10.3389/fmicb.2023.1207132 184

Noronha, S

Cell Death Differ 29 , 467480 (2022)

Neuroimaging evidence has revealed hypoactivity of the insula in ASD patients in response to social stimuli 48