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I'm now in my 50s and they are starting to get a bit irregular but in terms of pain - used to be bad when I was younger but started taking an iron supplement when I was in my 30s and that seemed to sort things out

However, very high doses taken over long periods can potentially cause nerve issues or mask other nutrient deficiencies

Some researchers have conceptually explored combining both strategies for potentially synergistic effects on intracellular NAD+ levels, though no published data exists for this specific combination

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This dual mechanism burning existing fat while preventing new fat accumulation makes it uniquely effective for long-term body composition improvement