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10.1016/j.cbpa.2010.11.003 68 CirulliE

The findings of the present study demonstrate that a high-fat, high-sucrose diet, which causes chronic hepatosteatosis similar to human fatty liver, reduces hepatic NAD + levels and consequently diminishes mitochondrial content, function, and adenosine triphosphate production

Quality glutathione supplements are generally well-tolerated

The main types of coumarins include esculetin, aesculin, umbelliferone, fraxetin, daphnetin, coumarin, and paepalentin

Indeed, when we undertook LCMS analysis of TCA cycle metabolites, ML226 treatment resulted in the accumulation of 2-OG and 2-HG, but this did not occur following DEG treatment, which increased only free glutarate (Fig