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The latter symptoms can be hard to differentiate from sarcoidosis-associated symptoms

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Importantly, increases in brain glutathione levels cannot be achieved through direct administration but rather through biosynthesis using amino acid substrates (cysteine, glutamate, and glycine)

Low glutathione has also been linked to eye issues like cataracts, macular degeneration, and glaucoma

[148] [157] It is for these reasons that clomipramine, in spite of potentially superior effectiveness to SSRIs, is now rarely used as a first-line agent in the treatment of OCD, with SSRIs being used as first-line therapies instead and clomipramine generally being reserved for more severe cases and as a second-line agent