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10.1186/1532-429X-10-42 99
The linker ligation and amplification of methylated fragments could add the affinity enrichment methods with array hybridization to enhance resolution and efficiency of detection including the MethylCap kit (Diagenode), and MethylCollector Ultra kit (Active Motif) with distinct fluorescent dye labeling of inputted and enriched fragments [24, 70]
It has been shown to skew the production away from the darker eumelanin and toward the lighter pheomelanin
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Initial dosing should be considered a starting point, with adjustments based on therapeutic response, tolerance, and evolving health needs
