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Sepsis-associated acute kidney injury (SA-AKI) is one of the most prevalent complications of sepsis and significantly elevates the mortality risk of affected patients ( 2 Dysregulated inflammatory response in SA-AKI The Systemic Inflammatory Response Syndrome (SIRS) plays a crucial role in the onset of sepsis and the subsequent development of organ dysfunction

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Bile acids can trigger mitochondrial ROS generation in hepatocytes that in turn act to mediate the inactivation of PTPs, resulting in the activation of EGFR (90)

L-glutathione defends against free radicals, while vitamin C supports strong bones, skin, and immunological function

The hepatoprotective activity of the plant extract was studied in CCl4-induced liver injury models of Wister albino rats