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Clinical descriptions of the JHR indicate that its definition should be broadened from chills, rising temperature, and intensification of skin rash to include sometimes meningitis, pulmonary failure, liver and renal dysfunction, myocardial injury, premature uterine contractions in pregnant patients, and worsening cerebral function as well as strokes and seizures

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doi: 10.1038/s41467-019-09735-4 113

Preliminary results of the first part of the PASADENA study (NCT03100149) showed that it did not meet the primary objective (i.e