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The DUOX1 and DUOX2 members of the NADPH oxidase family are involved in the generation of the the thyroid hormones
At the same time, the available publications mainly concern preclinical models and metabolic studies on the analogue of the AOD9604 , therefore interpretation of the results should take into account the experimental nature of this molecule and the fact that the scope of modern, high-quality clinical data is limited
As shown in Figure 8, the model group showed a lower content of GSH and an increasing tendency of MDA content in contrast with the control group, indicating that oxidative stress occurred in the model group
Niacin resulted in considerable dose-dependent increases in erythrocyte NAD + concentrations, with also subject-dependent dynamics of NAD + increase
