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With the advancement of research, the understanding of COPD etiology has expanded from exposure to harmful gases/particles to multiple etiological types. New classifications of COPD have emerged, including the pulmonary cachexia phenotype, COPD-bronchiectasis overlap phenotype, rapid progressive phenotype, non-smoking COPD phenotype, comorbidity/systemic phenotype, upper lobe-predominant emphysema phenotype, 1-antitrypsin deficiency phenotype, and early disease-related phenotypes (pre-COPD, early-onset COPD, preserved ratio impaired lung function) ( In contrast, an endotype represents the underlying biological or molecular mechanisms that produce these observable traits

In addition to ubiquitination, HMGCR is regulated via phosphorylation

But psychological dependence on symptom relief is possible with any effective treatment

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Assessment of the redox status in patients with metabolic syndrome and type 2 diabetes reveals great variations