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Presence of the rare minor allele re3583882 (p.R215W) in the transcobalamin gene is also associated with unmeasurable levels of holoTC in serum

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Gastric bypass surgery : This surgery alters the digestive system, reducing the bodys ability to absorb B12 from food and supplements.For these individuals, methylcobalamin B12 injections provide a direct way to bypass the digestive system and restore essential B12 levels

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