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Vitamin B12, a key nutrient responsible for many essential functions in the body, can sometimes be challenging to absorb through diet alone

Because standard gastrointestinal absorption of B12 is highly complex and easily disrupted by age, low stomach acid, medications, and chronic inflammation, therapeutic dosing often needs to be significantly higher than the standard Recommended Daily Allowance (RDA) of 2.4 mcg

Model 1 was adjusted for age (years, continuous variables), sex (male, female), and race/ethnicity (non-Hispanic white, black, Hispanic Mexican, or other)

MOTS-c is generally dosed once daily in the morning

There are no competing interests or conflicts of interest to declare