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At the endpoint, mice were euthanized and blood, spleen, kidney, liver and lung were collected and snap-frozen until further analysis

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The exception is HGF, which induced the expression of both GCL subunits in hepatocytes under low-density condition [29]

The specific reasons identified include intensive insulin therapy, decreased renal function, severe liver disease, alcohol ingestion, defective counter regulatory hormone release, missing meals/fasting, and gastroparesis