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Collectively, these findings indicate that MDMA has the potential to produce a distal axotomy of 5-HT neurons in rats and primates

This reduction correlated with impaired motor function and the development of compulsive drug-seeking behaviors ( MRI studies have further identified gray matter atrophy in the prefrontal cortex, medial cingulate gyrus, and hippocampus, regions that are critically involved in memory, decision-making, and emotional regulation ( Magnetic resonance spectroscopy provides complementary biochemical evidence of METH-induced neurotoxicity

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